Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome
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چکیده
منابع مشابه
Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome
AIM The aim of this study is to investigate whether nitric oxide (NO)-mediated colonic motility was altered in rat irritable bowel syndrome (IBS) model, using different isoforms of NO-synthase (NOS) inhibitors. MATERIALS AND METHODS The animal model of IBS-like visceral hypersensitivity was induced by intra-colonic infusion of 0.5% acetic acid (AA) in saline once daily from postnatal days 8 t...
متن کاملEffect of varenicline on colonic motility in a rat model of experimental irritable bowel
Aim: We aimed to investigate in vitro effects of varenicline on spontaneous contractile responses of proximal and distal colon smooth muscle in control and IBS rats. Methods: The animal model of IBS-like visceral hypersensitivity was induced by intra-colonic infusion of 0.5% Acetic Acid (AA) in saline once daily between postnatal days 8-21. Control animals received saline instead of AA. Experim...
متن کاملT-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome.
The symptoms of irritable bowel syndrome (IBS) include significant abdominal pain and bloating. Current treatments are empirical and often poorly efficacious, and there is a need for the development of new and efficient analgesics aimed at IBS patients. T-type calcium channels have previously been validated as a potential target to treat certain neuropathic pain pathologies. Here we report that...
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Background: Irritable bowel syndrome is one of the most common functional disorders of the digestive tract which causes a lot of problems for patients. Medicinal plants may decrease symptoms and improve patients` life. Objective: The aim of this study is to investigate the effectiveness of ginger on the symptoms of IBS. Methods: In this triple blind clinical trial, 64 patients with irritable...
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In 100 patients with irritable bowel syndrome a wide variety of non-gastrointestinal symptoms were significantly more common than in a group of 100 age, sex, and social class matched controls. Nocturia, frequency and urgency of micturition, incomplete bladder emptying, back pain, an unpleasant taste in the mouth, a constant feeling of tiredness and in women dyspareunia were particularly promine...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2016
ISSN: 0253-7613
DOI: 10.4103/0253-7613.186189